Faculty personal page

Professor Axel Guenther

PhD (Swiss Federal Institute of Technology, ETH, Zurich)

Areas of Research

The "lab-on-a-chip" concept of miniaturizing and integrating different laboratory processes takes advantage of controlled fluid flow behavior on small scales, allows reduced reagent consumption and automation. The Guenther Research Group at the University of Toronto draws from the areas of fluid mechanics, colloidal material synthesis, as well as micro/nanofabrication. We investigate fundamentals of transport processes associated with micro/nanoscale flows and aim at translating these fundamentals into powerful technical solutions.

We are particularly interested in realizing dynamically changing microenvironments for applications in materials science and biomedicine. Current applications include (1) the controlled preparation of organized colloidal and bulk materials, (2) high-throughput platforms for microvascular research and biopharmaceutical drug discovery, and (3) microfluidic strategies for probing complex cellular decision processes.

Professor Guenther is cross-appointed at the Institute of Biomaterials and Biomedical Engineering.

The following links will lead you to the websites of the Guenther Research Group and the Microfluidics Foundry.

Open Positions

We are looking for bright graduate and undergraduate students in a number of exciting, microfluidics-related projects. We put a large emphasis on involving undergraduate students in our research and also have several fourth-year thesis projects available. For prospective graduate students, undergraduate experience in different engineering disciplines is very welcome.

Please get in touch if you are interested and send your resume/transcripts along!

Teaching

Graduate Course MIE1232S - Microfluidics and Lab-on-a-Chip Systems (Winter 2011)

Undergraduate Course MIE414S - Applied Fluid Mechanics (Winter 2011)

6th Microfluidics Event "Ontario-on-a-Chip" and 2nd NSERC CREATE MATCH Symposium, June 9-10, 2011, Toronto

Contact

Department of Mechanical and Industrial Engineering
University of Toronto
5 King's College Road
Toronto, Ontario M5S 3G8

Email
Tel 416-978-1282
Fax 416-978-7753

Selected Publications

Guenther, A; Yasotharan, S; Vagaon, A, et al. "A microfluidic platform for probing small artery structure and function" Lab Chip. 10(18), 2341-2349, 2010. Highlight article and related YouTube Video

Park, I., Saffari, A. Kumar, S. et al. "Microfluidic synthesis of polymer and inorganic particulate materials" Ann. Rev. Mat. Sci. 40(40), 415-443, 2010.

de Mas, N., Guenther, A., Schmidt, M.A., Jensen, K.F. "Increasing productivity of microreactors for fast gas-liquid reactions: the case of direct fluorination of toluene" Ind. & Eng. Chem. Res. 48(3), 1428-1434, 2009.

Kreutzer, M.T., Guenther, A., Jensen, K.F. "Sample dispersion for segmented flow in microchannels with rectangular cross section" Anal. Chem. 80 (5), 1558-1567, 2008.

Muradoglu, M., Guenther, A., Stone, H.A. "A computational study of axial dispersion in segmented gas-liquid flow" Physics of Fluids 19 (7) 072109, 2007.

Guenther, A., Jensen, K.F. "Multiphase microchemical systems: from flow characteristics to chemical and materials synthesis," Lab on a Chip, 6, 1487-1503, 2006.

Guenther, A., Jhunjhunwala, M., Thalmann, M., Schmidt, M.A., and Jensen, K.F. "Micromixing of miscible liquids in segmented gas-liquid flow" Langmuir, 21 (4), 1547-1555, 2005.

Yen, B.K.H., Guenther, A., Schmidt, M.A., Jensen, K.F., Bawendi, M.G. "A microfabricated gas-liquid segmented flow reactor for high temperature synthesis: the case of CdSe quantum dots" Ang. Chemie, Int. Ed., 44 (34), 2005.

Guenther, A., Khan, S.A., Trachsel, F., Thalmann, M., Jensen, K.F. "Transport and reaction in microscale segmented flow" Lab on a Chip, 4, pp. 278-286, 2004.